Dialyzer

RenEge PURIFIER Class Dialyzers with Polyethersulfone Membrane (Hydrophilic)

RenEge's Sanithum Dialyzer group is one of the latest new technology first class dıalyzers showıng an excellent performance. The capillaries are made of MEMBRANA's new technology outstanding PUREMA Polyethersulfone membranes. RenEge's dialyzers is composed of mainly low, and high flux series, each kind with various surface areas, 1.0m², 1.2, 1.4, 1.6, 1.8, 2.0, which makes it available to respond to patients needs and all therapeutic requirements.

A wide spectrum of toxins pass through the membrane in accordance with exact membrane properties.The outstanding synthetic Polyethersulfone membranes are more biocompatible, and therefore are less likely to stimulate the body’s immune system. This minimizes the allergic symptoms as well as various disadvantages of less biocompatible membranes. Primarily (Polyethersulfone (PES) membrane for aqueous solutions provides removal of viruses, bacteria, fine particles and fungi making it a special membrane for sterile filtration.

PURIFIER dialyzer has evıdenced its extensıve capability in terms of Clearance and diffusive permeability. The PUREMA Polyethersulfone membrane of this dialyzer has a thinner wall than traditional synthetic membranes. This thin-walled structure gives higher ultrafiltration rates and improved performance through the shortening of the diffusion distance.

The new pore forming technology of PURIFIER dıalyzer membrane, decreases resistance to dialysate flow, leaving minimum dead spaces, and thus allows for extensive capillary utilization providing maximum Clearance possible.

Why Polyethersulfone (PES) dialyzers?

Since both blood and dialysate have aqueous structure, the dialysis membrane also should rather be hydrophilic. In addition to the characteristics indicated before, due to Polyethersulfone's inherently hydrophilic structure, it wets out quickly and completely, resulting in fast filtration with better flow rates and high throughputs. Thanks to the hydrophilic structure of PES no additional surfactants are used to increase wettability. Extremely low protein binding structure of PES membrane minimizes the possibility of target analytic binding. At RenEge we sterilize Polyethersulfone membrane with oxygen free gamma radiation method which is a very safe way of sterilization for our dialyzers.

Sanithum High-Flux Dialyzer

PURIFIER H SYNTHETIC HIGH-FLUX DIALYSERS

A member of Sanithum Family, proven clinical record, renowned biocompatibility,

The capillaries are made of Membrana's new technology PUREMA Polyethersulfone membranes. Clinical studiew proved outstanding performance of Purifer High-Flux Dialyzers thanks to its new technology Polyethersulfone membrane structure.

• Excellent and stable clearances throughout the treatment
• Significantly enhanced LMW protein removal
• Low albümin loss
• Excellent biocompatibility of advanced synthetic membrane significantly lower complement generation
• Steeper sieving profile
• Oxygen-free gamma sterilization maintains membrane integrity
• Caps on dialysate ports help prevent contamination
• Wide range of sizes to better match performance to patient needs

Technical Data

	PURIFIER High-flux   120	PURIFIER High-flux    140	PURIFIER High-flux    160	PURIFIER High-flux    180	PURIFIER High-flux    200
Effective Membrane Area (m2)	1,2 m2	1,4 m2	1,6 m2	1,8 m2	2,0 m2
Priming Volume (mL)	67	74	87	96	108
UF Coefficient (mL/h/mmHg)	52	58	67	75	84
KoA Urea (Qk300 ml/min, Qd500 ml/min.)	849	961	1083	1214	1382
Membrane	Polyethersulfone (PES)
Sterilisation	Gamma Rays
Max. TMP	600 mmHg
Wall Thickness	30µm
Inner Diameter	200µm

Specifications & performance data at clearance in vitro (ml/min) Qk=300 ml/min, Qd=500 ml/min, Qf=0 ml/min,T=37 OC.

KUF measurement using bovine blood (Hct % 32; Protein 60 g/L)

Performance data were measured in vitro according to standard EN 1283.

Info

The term high-flux dialysis refers to a form of hemodialysis that was developed in recent years to improve the efficiency of dialysis. It has succeeded in both improving the quality of dialysis and in shortening dialysis times.

The essential element of high-flux dialysis is the use of dialyzers (artificial kidneys) that have larger pores for the removal both of uremic toxins and of fluid. Blood urea nitrogen (BUN) is measured and followed as a reflection of all the toxins that the kidney normally removes. With high-flux dialysis, BUN clearly is removed more quickly. But there is also now evidence that larger molecules may also play an important role in causing the uremic symptoms that are both annoying and dangerous to dialysis patients. Such molecules are too big to be removed by conventional dialysis, but are removed with high flux dialyzers. For example, a molecule called beta 2 microglobulin, which can have a role in causing arthritis in dialysis patients, is removed only by high-flux dialysis. In fact there are already reports of patients with less joint pain when switched from conventional to high-flux dialysis. Thus, the removal of larger molecules may prove to be a crucial benefit of high flux dialysis.

The larger pore size with high-flux dialysis also allows much faster removal of fluid. Because of the risk of removing fluid too fast, and causing dangerous drops in blood pressure, a special device, called an ultrafiltration controller, is required. This device allows precise regulation of the volume that is removed, and avoids ever overshooting the amount removed. It also allows the accurate removal of very small volumes, as well as volumes up to four liters per hour, which can never be achieved with conventional dialysis. Finally, since the fluid is removed continuously and evenly, removal of large volumes is better tolerated with fewer symptoms.

Another important aspect of high-flux dialysis is that higher blood and dialysate flows are used. With conventional dialysis, increasing the rate of blood flow (for example above 300 ml/min) minimally increases the amount of dialysis. In contrast, with high-flux dialyzers, when blood flow is increased up to 450 ml/min, significant improvements in dialysis efficiency can be obtained. Similarly, increasing the rate of dialysate flow allows faster removal of the toxins that are being cleared.

Nephrologists typically use some form of the technique called urea kinetic modeling to determine their dialysis prescription. Using national standards for adequacy of dialysis, and after taking residual renal function into account, urea kinetic modeling uses the dialyzer’s performance characteristics and the patient’s weight to derive an estimate of the time required for dialysis. Since high-flux dialysis (also called high efficiency dialysis in some centers) is so much more efficient, it can allow significant reduction of dialysis times, often by 25 percent. Thus, the patient receives adequate dialysis, but minimizes the discomfort of long dialysis times. However, it is important to note that adequacy of dialysis must be maintained. Some patients may not be able to greatly shorten dialysis times when switching from conventional to high flux dialysis.

Several other aspects of modern dialysis, including the use of bicarbonate dialysate, are an essential part of high-flux dialysis. However, they are now typically part of conventional dialysis as well. Bicarbonate is now routinely used as the dialysate buffer because the acetate that was used previously caused dilatation of blood vessels and resulted in low blood pressure. Another characteristic of high-flux dialysis is that the membranes used are more biocompatible, and therefore are less likely to stimulate the body’s immune system. This minimizes the allergic symptoms as well as the changes in white blood cell counts that were previously caused by less biocompatible membranes.

The major possible disadvantage of high flux dialysis regards pyrogen reactions. These reactions, characterized by high temperatures in patients during dialysis treatments, are caused by small pieces of dead bacteria that can be found in the dialysate. Although these reactions are not dangerous, they are uncomfortable for patients, and typically require short hospitalizations for observation. Some nephrologists feel that because high flux dialyzers have larger pores, the bacterial particles can pass more easily into the patient’s bloodstream, and that patients on high flux dialysis have more frequent pyrogen reactions. This observation remains to be confirmed.

Patients are not required to make any changes from their point of view in using high flux dialysis. Typically, they actually feel better, especially in terms of having less post-dialysis fatigue. High flux dialysis requires only minor technical adjustments in the dialyzing system, and will continue to be adopted by more and more dialysis centers.

Reference

• http://msl1.mit.edu/ESD10/kidneys/HndbkHTML/ch3.htm Didier Mandelbrot, M.D.

Export Info

PRODUCT	FOR 1 PCS 80*120 cm EURO PALLET	GROSS WEIGHT
Dialysers	720 PCS	200 Kg

MANNER OF DELIVERY	QUANTITY OF PALLET CONTAINED
40 FOOT CONTAINER	23 PALLET (80*120 EURO)
20 FOOT CONTAINER	11 PALLET (80*120 EURO)
STANDART TRUCK	30 PALLET (80*120 EURO)

Sanithum Low-Flux Dialyzer

Efficient Sanithum L for low-flux therapies

Sanithum Low-flux dialyzers provıdes an excellent low flux therapy. The capillaries are made of Membrana's new technology PUREMA Polyethersulfone membranes. Its outstanding Polyethersulfon membrane provides optimum clearence value and stability. Thanks to its new technology inherently hydrophilic membrane structure, risk of micro inflammation and thrombogenic possibilities are minimized.

• Advanced Polyethersulfone membrane delivers excellent clearances
• Urea clearance on high level
• Improved performance concerning creatinine, phosphate, vitaminB12 clearance
• Excellent biocompatibility of advanced synthetic membrane
• Oxygen-free gamma sterilization maintains membrane integrity
• Caps on dialysate ports help prevent contamination
• Wide range of sizes to better match performance to patient needs
• High end low flux membrane/ one of the best Low flux dialyzers in the market

Technical Data

	PURIFIER Low-flux 120	PURIFIER Low-flux 140	PURIFIER Low-flux 160	PURIFIER Low-flux 180	PURIFIER Low-flux 200
Effective Membrane Area (m2)	1,2 m2	1,4 m2	1,6 m2	1,8 m2	2,0 m2
Priming Volume (mL)	65	78	86	98	107
UF Coefficient (mL/h/mmHg)	16	19	21	24	26
KoA Urea (Qk300 ml/min, Qd500 ml/min.)	767	824	888	961	1027
Membrane	Polyethersulfone (PES)
Sterilisation	Gamma Rays
Max. TMP	600 mmHg
Wall Thickness	35µm
Inner Diameter	200µm

Specifications & performance data at clearance in vitro (ml/min) Qk=300 ml/min, Qd=500 ml/min, Qf=0 ml/min,T=37OC.

KUF measurement using bovine blood (Hct % 32; Protein 60 g/L)

Performance data were measured in vitro according to standard EN 1283.

Export Info

PRODUCT	FOR 1 PCS 80*120 cm EURO PALLET	GROSS WEIGHT
PURIFIER Dialyzsers	720 PCS	200 Kg

MANNER OF DELIVERY	QUANTITY OF PALLET CONTAINED
40 FOOT CONTAINER	23 PALLET (80*120 EURO)
20 FOOT CONTAINER	11 PALLET (80*120 EURO)
STANDART TRUCK	30 PALLET (80*120 EURO)